Cutting Edge Technology at the Stanford University School of Medicine
Publications Supported by SoM Service Centers
Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic beta Cells. Cell Chemical Biology. 2019;26:1-10.
facilities: BioADD, FACS A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library. mAbs. 2018;10:431-443.
facilities: FACS Imaging activated T cells predicts response to cancer vaccines. The Journal of Clinical Investigation. 2018;128:2569-2580.
facilities: FACS, HIMC, SCi3 Magnetically Guided Self‐Assembly and Coding of 3D Living Architectures. Advanced Materials. 2018;30:1705034.
facilities: NMS Ultrafast epithelial contractions provide insights into contraction speed limits and tissue integrity. Proceedings of the National Academy of Sciences. 2018.
facilities: CSIF Probabilistic Prognostic Estimates of Survival in Metastatic Cancer Patients (PPES-Met) Utilizing Free-Text Clinical Narratives. Sci Rep. 2018;8:10037.
facilities: DCC KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects. Molecular Immunology. 2018.
facilities: HIMC 18F-florbetaben whole-body PET/MRI for evaluation of systemic amyloid deposition. EJNMMI Research. 2018;8:66.
facilities: PET-MRI Novel Genes and Regulators That Influence Production of Cell Surface Exopolysaccharides in Sinorhizobium meliloti. Journal of Bacteriology. 2018;200.
facilities: PAN Regulation of epithelial migration by epithelial cell adhesion molecule requires its Claudin-7 interaction domain. PLOS ONE. 2018;13:e0204957.
facilities: FACS A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells. JoVE. 2018:e57361.
facilities: FACS Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin. Molecular Biology of the Cell. 2018;29:1571-1589.
facilities: FACS, PAN Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts. eLife. 2018;7:e27024.
facilities: SFGF A Combination of Ontogeny and CNS Environment Establishes Microglial Identity. Neuron. 2018;98:1170-1183.e8.
facilities: FACS, NMS Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia. Genome Res. 2018.
facilities: Genome Sequencing, HIMC, SFGF Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Molecular Neurodegeneration. 2018;13:68.
facilities: GVVC Optical probing of orexin/hypocretin receptor antagonists. Sleep. 2018:zsy141.
facilities: GVVC, NMS High-quality genome sequences of uncultured microbes by assembly of read clouds. Nature Biotechnology. 2018;36:1067.
facilities: GBSC Robust B Cell Responses Predict Rapid Resolution of Lyme Disease. Frontiers in Immunology. 2018;9.
facilities: FACS, SFGF Gelatin-Based Microribbon Hydrogels Accelerate Cartilage Formation by Mesenchymal Stem Cells in Three Dimensions. Tissue Engineering Part A. 2018;24:1631-1640.
facilities: CSIF Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. PLOS Biology. 2018;16:e2005895.
facilities: PAN A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Nature Genetics. 2018;50:460-471.
facilities: FACS Concordant Changes in Gene Expression and Nucleotides Underlie Independent Adaptation to Hydrogen-Sulfide-Rich Environments. Genome Biology and Evolution. 2018;10:2867-2881.
facilities: Genome Sequencing, SFGF MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. Proceedings of the National Academy of Sciences. 2018;115:E12407-E12416.
facilities: SBFNL Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory. Science. 2018;359:787-790.
facilities: NMS, SBFNL EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. Nature. 2018;558:313-317.
facilities: FACS Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet–Induced Metabolic Dysfunction in Mice. Journal of Pharmacology and Experimental Therapeutics. 2018;365:281-290.
facilities: BioADD Identification of the Human Skeletal Stem Cell. Cell. 2018;175:43-56.e21.
facilities: SFGF PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke. JoVE. 2018:e57243.
facilities: SCi3 Telomere shortening is a hallmark of genetic cardiomyopathies. Proceedings of the National Academy of Sciences. 2018;115:9276-9281.
facilities: CSIF Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. Nature communications. 2018;9:4590.
facilities: SFGF Rapid and specific labeling of single live Mycobacterium tuberculosis with a dual-targeting fluorogenic probe. Science Translational Medicine. 2018;10: eaar4470.
facilities: FACS, NMS, SCi3, SFGF Dynamin impacts homology-directed repair and breast cancer response to chemotherapy. The Journal of Clinical Investigation. 2018;128.
facilities: DCC, HTBC, NMS Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell. 2018;173:1385-1397.e14.
facilities: FACS, HIMC Guidance and Self-Sorting of Active Swimmers: 3D Periodic Arrays Increase Persistence Length of Human Sperm Selecting for the Fittest. Advanced Science. 2018;5:1700531.
facilities: CSIF Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. Scientific Reports. 2018;8:14008.
facilities: FACS Ultrasensitive optical imaging with lanthanide lumiphores. Nature Chemical Biology. 2018;14:15.
facilities: HTBC Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018;173:1398-1412.e22.
facilities: SFGF, TKTC 2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation. Nature Structural & Molecular Biology. 2018;25:208-216.
facilities: PAN Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nature communications. 2018;9:4906.
facilities: Animal Histology, NMS, SFGF 18F-FDG PET/MRI in Chronic Sciatica: Early Results Revealing Spinal and Non-spinal Abnormalities. Journal of Nuclear Medicine. 2018.
facilities: PET-MRI Successful treatment of chronic knee pain following localization by a sigma-1 receptor radioligand and PET/MRI: a case report. J Pain Res. 2018;11:2353-2357.
facilities: PET-MRI The chromatin accessibility landscape of primary human cancers. Science. 2018;362:eaav1898.
facilities: SFGF Population genomic analyses of the chocolate tree, Theobroma cacao L., provide insights into its domestication process. Communications Biology. 2018;1:167.
facilities: SFGF Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. eLife. 2018;7:e39945.
facilities: GVVC Surface-Enhanced Raman Scattering Nanoparticles for Multiplexed Imaging of Bladder Cancer Tissue Permeability and Molecular Phenotype. ACS Nano. 2018;12:9669-9679.
facilities: FACS Complete motif analysis of sequence requirements for translation initiation at non-AUG start codons. Nucleic Acids Research. 2018;46:985-994.
facilities: FACS PET Imaging Stability Measurements During Simultaneous Pulsing of Aggressive MR Sequences on the SIGNA PET/MR System. Journal of Nuclear Medicine. 2018;59:167-172.
facilities: PET-MRI Evaluation of marine zooplankton community structure through environmental DNA metabarcoding. Limnology and Oceanography: Methods. 2018;16:209-221.
facilities: SFGF Activity-dependent modulation of hippocampal synaptic plasticity via PirB and endocannabinoids. Molecular Psychiatry. 2018.
facilities: SBFNL MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Molecular Cell. 2018;70:936-948.e7.
facilities: FACS Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell–mediated remissions. Blood Advances. 2018;2:2568-2580.
facilities: FACS Tumor characterization by ultrasound-release of multiple protein and microRNA biomarkers, preclinical and clinical evidence. PLOS ONE. 2018;13:e0194268.
facilities: SCi3 High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites. Frontiers in Cellular and Infection Microbiology. 2018;8.
facilities: HTBC Transcriptional Dynamics of Hair-Bundle Morphogenesis Revealed with CellTrails. Cell reports. 2018;23:2901-2914.e14.
facilities: FACS Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing. PLoS pathogens. 2018;14:e1007094.
facilities: FACS Programmed cell removal by calreticulin in tissue homeostasis and cancer. Nature communications. 2018;9:3194.
facilities: HIMC, SCi3 Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation. eLife. 2018;7:e35989.
facilities: Genome Sequencing, SFGF Purification of GFRα1+ and GFRα1- Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination. Stem Cell Reports. 2018;10:553-567.
facilities: FACS, NMS Prochemerin cleavage by factor XIa links coagulation and inflammation. Blood. 2018;131:353-364.
facilities: PAN Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nature Neuroscience. 2018;21:1084-1095.
facilities: GVVC, NMS Interdependent and separable functions of Caenorhabditis elegans MRN-C complex members couple formation and repair of meiotic DSBs. Proceedings of the National Academy of Sciences. 2018;115:E4443-E4452.
facilities: CSIF Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site. Cell Chemical Biology. 2018;25:185-193.e5.
facilities: HTBC Direct Selection Strategy for Isolating Aptamers with pH-Sensitive Binding Activity. ACS Sensors. 2018;3:2574-2580.
facilities: SFGF GABA editing with macromolecule suppression using an improved MEGA‐SPECIAL sequence. Magnetic Resonance in Medicine. 2018;79:41-47.
facilities: Lucas Cryopreservation of Peripheral Blood Mononuclear Cells from Whole Blood. In: Hubel A, editor. John Wiley & Sons; 2018. 1. p. 125-130p.
facilities: HIMC mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice. Proceedings of the National Academy of Sciences. 2018;115:E9153-E9161.
facilities: FACS, SCi3 Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent 11C-raclopride positron emission tomography and functional magnetic resonance imaging investigation. Translational Psychiatry. 2018;8:264.
facilities: PET-MRI 2D multi-spectral imaging for fast MRI near metal. Magnetic Resonance in Medicine. 2018;79:968-973.
facilities: Lucas Toxoplasma gondii infection triggers chronic cachexia and sustained commensal dysbiosis in mice. PLOS ONE. 2018;13:e0204895.
facilities: Animal Histology, HIMC, SCi3 Variable refocusing flip angle single-shot fast spin echo imaging of liver lesions: increased speed and lesion contrast. Abdominal Radiology. 2018;43:593-599.
facilities: PET-MRI A Guide to Single-Cell Transcriptomics in Adult Rodent Brain: The Medium Spiny Neuron Transcriptome Revisited. Frontiers in Cellular Neuroscience. 2018;12.
facilities: FACS Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy. Proceedings of the National Academy of Sciences. 2018;115:E9182-E9191.
facilities: HIMC, SCi3 Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nature Structural & Molecular Biology. 2018;25:61-72.
facilities: CSIF [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis. Journal of Neuroinflammation. 2018;15:55.
facilities: PAN, SCi3 Multiregion Quantification of Extracellular Signal-regulated Kinase Activity in Renal Cell Carcinoma. European Urology Oncology. 2018.
facilities: TASC Phosphoethanolamine cellulose enhances curli-mediated adhesion of uropathogenic Escherichia coli to bladder epithelial cells. Proceedings of the National Academy of Sciences. 2018;115:10106-10111.
facilities: CSIF Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation. Science Translational Medicine. 2018;10.
facilities: BioADD Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells. Oncotarget. 2018;9:11665-11676.
facilities: SFGF Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith–Magenis syndrome. Proceedings of the National Academy of Sciences. 2018;115:10744-10749.
facilities: SBFNL, TKTC Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nature communications. 2018;9:4045.
facilities: HTBC A convex 3D deconvolution algorithm for low photon count fluorescence imaging. Scientific Reports. 2018;8:11489.
facilities: CSIF High-resolution 3D volumetric contrast-enhanced MR angiography with a blood pool agent (ferumoxytol) for diagnostic evaluation of pediatric brain arteriovenous malformations. Journal of Neurosurgery: Pediatrics. 2018;22:251-260.
facilities: Lucas StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nature Methods. 2018;15:523-526.
facilities: FACS Prediction of preterm birth with and without preeclampsia using mid-pregnancy immune and growth-related molecular factors and maternal characteristics. Journal of Perinatology. 2018;38:963-972.
facilities: HIMC Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner. Frontiers in Endocrinology. 2018;9.
facilities: SFGF Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease. Oncotarget. 2018;9:6128-6143.
facilities: SBFNL Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis. EMBO Molecular Medicine. 2018.
facilities: CSIF, SBFNL Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma. Nature communications. 2018;9:4121.
facilities: SCi3
facilities: GVVC
Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq. Stem Cell Research & Therapy. 2018;9:292.
facilities: Image-derived input function estimation on a TOF-enabled PET/MR for cerebral blood flow mapping. Journal of Cerebral Blood Flow & Metabolism. 2018;38:126-135.
facilities: PET-MRI Replication study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. eLife. 2018;7:e39944.
facilities: TKTC Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains. The Journal of Neuroscience. 2018;38:10672-10691.
facilities: BioADD, CSIF Quantitative imaging of bone–cartilage interactions in ACL-injured patients with PET–MRI. Osteoarthritis and Cartilage. 2018;26:790-796.
facilities: PET-MRI Rapid chromatin repression by Aire provides precise control of immune tolerance. Nature Immunology. 2018;19:162-172.
facilities: FACS Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo. Scientific Reports. 2018;8:14034.
facilities: CSIF, SBFNL CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Nature Genetics. 2018.
facilities: NMS Intracranial Electrophysiology Reveals Reproducible Intrinsic Functional Connectivity within Human Brain Networks. The Journal of Neuroscience. 2018;38:4230-4242.
facilities: Lucas Comparison of cell-based assays to quantify treatment effects of anticancer drugs identifies a new application for Bodipy-L-cystine to measure apoptosis. Scientific Reports. 2018;8:16363.
facilities: SCi3 Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma. Journal for ImmunoTherapy of Cancer. 2018;6:125.
facilities: Human Histology, SCi3 Most Sinorhizobium meliloti Extracytoplasmic Function Sigma Factors Control Accessory Functions. mSphere. 2018;3:e00454-18.
facilities: PAN SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation. Cell Stem Cell. 2018;22:428-444.e5.
facilities: GBSC, Genome Sequencing Characterization of dermatitis after PD-1/PD-L1 inhibitor therapy and association with multiple oncologic outcomes: A retrospective case-control study. Journal of the American Academy of Dermatology. 2018;79:1047-1052.
facilities: DCC Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix. Nature Biomedical Engineering. 2018;2:104-113.
facilities: BioADD, SCi3 Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science. 2018;359:1277-1283.
facilities: FACS Comparison of CyTOF assays across sites: Results of a six-center pilot study. Journal of Immunological Methods. 2018;453:37-43.
facilities: HIMC Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome. Journal of Neuroinflammation. 2018;15:105.
facilities: HIMC Decoding the Genomics of Abdominal Aortic Aneurysm. Cell. 2018;174:1361-1372.e10.
facilities: GBSC Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma. Acta Neuropathologica Communications. 2018;6:51.
facilities: HIMC, SFGF Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature. 2018;556:244-248.
facilities: NMS Mass Cytometry Assays for Antigen-Specific T Cells Using CyTOF. In: Hawley TS, Hawley RG, editors. Vol 1678. New York, NY: Springer New York; 2018. 3. p. 37-47p.
facilities: HIMC Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults. Journal of Translational Medicine. 2018;16:153.
facilities: HIMC Whole-genome sequencing reveals the extent of heterozygosity in a preferentially self-fertilizing hermaphroditic vertebrate. Genome. 2018;61:241-247.
facilities: Genome Sequencing, SFGF Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Nature. 2018;553:228.
facilities: SFGF Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid. Scientific Reports. 2018;8:12960.
facilities: GBSC, Genome Sequencing, NMS Single upconversion nanoparticle imaging at sub-10 W cm−2 irradiance. Nature Photonics. 2018.
facilities: CSIF Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation. Scientific Reports. 2018;8:11312.
facilities: CSIF Multiparameter Intracellular Cytokine Staining. In: Hawley TS, Hawley RG, editors. New York, NY: Springer New York; 2018. 1. p. 151-166p.
facilities: HIMC Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy. Proceedings of the National Academy of Sciences. 2018;115:E12323-E12332.
facilities: BioADD, Genome Sequencing, HIMC Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells. Circulation. 2018;138:2666-2681.
facilities: CSIF, NMS Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD. Nature Neuroscience. 2018;21:373-383.
facilities: GVVC Controlled Delivery of a Focal Adhesion Kinase Inhibitor Results in Accelerated Wound Closure with Decreased Scar Formation. Journal of Investigative Dermatology. 2018;138:2452-2460.
facilities: BioADD A screen for deeply conserved non-coding GWAS SNPs uncovers a MIR-9-2 functional mutation associated to retinal vasculature defects in human. Nucleic Acids Research. 2018;46:3517-3531.
facilities: CSIF Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model. Oncotarget. 2018;9:21478-21494.
facilities: PAN A Macrophage Colony-Stimulating Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence. Immunity. 2018.
facilities: GBSC Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii. Vol 14.; 2018. (PLoS Pathog; vol 14).
facilities: NMS Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss. eLife. 2018;7:e36248.
facilities: CSIF Transcriptional Response of Staphylococcus aureus to Sunlight in Oxic and Anoxic Conditions. Frontiers in Microbiology. 2018;9.
facilities: PAN, SFGF Thymidine Kinase PET Reporter Gene Imaging of Cancer Cells In Vivo. In: Dubey P, editor. New York, NY: Springer New York; 2018. 1. p. 137-151p.
facilities: SCi3 Enhanced mRNA delivery into lymphocytes enabled by lipid-varied libraries of charge-altering releasable transporters. Proceedings of the National Academy of Sciences. 2018;115:E5859-E5866.
facilities: FACS, SCi3 Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. Proceedings of the National Academy of Sciences. 2018;115:5064-5071.
facilities: GVVC Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate. Journal of Biological Chemistry. 2018;293:20123-20136.
facilities: TKTC Development of a Protease Biosensor Based on a Dimerization-Dependent Red Fluorescent Protein. ACS Chemical Biology. 2018;13:66-72.
facilities: FACS PEG/Dextran Double Layer Influences Fe Ion Release and Colloidal Stability of Iron Oxide Nanoparticles. Scientific Reports. 2018;8:4286.
facilities: BioADD Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Vol 8.; 2018. (Sci Rep; vol 8).
facilities: HIMC Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas. Nature Medicine. 2018.
facilities: SCi3 Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLOS Genetics. 2018;14:e1007755.
facilities: PAN
facilities: SFGF
Dosimetry Prediction for Clinical Translation of 64Cu-Pembrolizumab ImmunoPET Targeting Human PD-1 Expression. Scientific Reports. 2018;8:633.
facilities: SCi3 Organoid Modeling of the Tumor Immune Microenvironment. Cell. 2018;175:1972-1988.e16.
facilities: Animal Histology, SFGF Comparison of Genomic Driver Oncogenes in Vietnamese Patients With Non–Small-Cell Lung Cancer in the United States and Vietnam. Journal of Global Oncology. 2018:1-9.
facilities: DCC QFMatch: multidimensional flow and mass cytometry samples alignment. Vol 8.; 2018. (Sci Rep; vol 8).
facilities: FACS Computed Tomography Features associated With the Eighth Edition TNM Stage Classification for Thymic Epithelial Tumors. Journal of Thoracic Imaging. 2018;33:176-183.
facilities: DCC Internalization of subcellular-scale microfabricated chips by healthy and cancer cells. PLOS ONE. 2018;13:e0194712.
facilities: CSIF Methodology for evaluating and comparing flow cytometers: A multisite study of 23 instruments. Cytometry Part A. 2018;93:1087-1091.
facilities: FACS Brain basis of cognitive resilience: Prefrontal cortex predicts better reading comprehension in relation to decoding. PLOS ONE. 2018;13:e0198791.
facilities: Lucas Bioengineered Viral Platform for Intramuscular Passive Vaccine Delivery to Human Skeletal Muscle. Molecular Therapy - Methods & Clinical Development. 2018;10:144-155.
facilities: SCi3 A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018;9:21495-21511.
facilities: PAN, SCi3 MR imaging of magnetic ink patterns via off-resonance sensitivity. Magnetic Resonance in Medicine. 2018;80:2017-2023.
facilities: Lucas Integrative Personal Omics Profiles during Periods of Weight Gain and Loss. Cell Systems. 2018.
facilities: GBSC, Genome Sequencing, HIMC Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin. Proceedings of the National Academy of Sciences. 2018;115:8781-8786.
facilities: HIMC In vitro and in vivo evaluation of cephalosporins for the treatment of Lyme disease. Drug Des Devel Ther. 2018;12:2915-2921.
facilities: BioADD Mechanical loading of desmosomes depends on the magnitude and orientation of external stress. Nature communications. 2018;9:5284.
facilities: CSIF, FACS Timing of host feeding drives rhythms in parasite replication. PLoS pathogens. 2018;14:e1006900.
facilities: HIMC Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage. The Journal of Immunology. 2018;200:1146-1158.
facilities: FACS, PAN Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23. Frontiers in Physiology. 2018;9.
facilities: GBSC, SFGF Macrophages Promote Circulating Tumor Cell–Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients. Cancer Research. 2018;78:4241-4252.
facilities: DCC Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis. Journal of Neuroinflammation. 2018;15:270.
facilities: PAN Differences in multiple immune parameters between Indian and U.S. infants. PLOS ONE. 2018;13:e0207297.
facilities: HIMC Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem®-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke. International Journal of Molecular Sciences. 2018;19:3782.
facilities: SBFNL pH Dependence of Zika Membrane Fusion Kinetics Reveals an Off-Pathway State. ACS Central Science. 2018;4:1503-1510.
facilities: PAN A collagen based cryogel bioscaffold coated with nanostructured polydopamine as a platform for mesenchymal stem cell therapy. Journal of Biomedical Materials Research Part A. 2018.
facilities: NMS, SCi3 An oxygen plasma treated poly(dimethylsiloxane) bioscaffold coated with polydopamine for stem cell therapy. Journal of Materials Science: Materials in Medicine. 2018;29:54.
facilities: NMS, SCi3 High-frequency actionable pathogenic exome variants in an average-risk cohort. Molecular Case Studies. 2018;4.
facilities: GBSC Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell. 2018;175:472-487.e20.
facilities: GVVC Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema. JCI Insight. 2018;3:1-11.
facilities: HIMC Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice. Nature Genetics. 2018.
facilities: SCi3 The outer membrane is an essential load-bearing element in Gram-negative bacteria. Nature. 2018;559:617-621.
facilities: CSIF Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine. Proceedings of the National Academy of Sciences. 2018;115:7081-7086.
facilities: CSIF, FACS Eradication of spontaneous malignancy by local immunotherapy. Science Translational Medicine. 2018;10.
facilities: SCi3 Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proceedings of the National Academy of Sciences. 2018;115:6279-6284.
facilities: CSIF, SFGF WISP3 mutation associated with pseudorheumatoid dysplasia. Molecular Case Studies. 2018;4.
facilities: Genome Sequencing An intrinsic S/G2 checkpoint enforced by ATR. Science. 2018;361:806-810.
facilities: SFGF Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M. Nature communications. 2018;9:1531.
facilities: FACS, SCi3 Transcript-indexed ATAC-seq for precision immune profiling. Nature Medicine. 2018;24:580-590.
facilities: SFGF Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Proceedings of the National Academy of Sciences. 2018;115:E10235-E10244.
facilities: GVVC Distinctive Roles for Type I and Type II Interferons and Interferon Regulatory Factors in the Host Cell Defense against Varicella-Zoster Virus. Journal of Virology. 2018;92:e01151-18.
facilities: FACS, SFGF Architecture and Implementation of a Clinical Research Data Warehouse for Prostate Cancer. EGEMS (Wash DC). 2018;6:13.
facilities: DCC Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018;50:180-185.
facilities: GVVC TSPO–PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75NTR ligand LM11A-31. Human Molecular Genetics. 2018;27:2893-2912.
facilities: HIMC, SCi3 Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science. 2018;359:1037-1042.
facilities: HIMC Simultaneous Optogenetics and Cellular Resolution Calcium Imaging During Active Behavior Using a Miniaturized Microscope. Frontiers in Neuroscience. 2018;12.
facilities: GVVC, NMS Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients. Journal for ImmunoTherapy of Cancer. 2018;6:18.
facilities: HIMC Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis. Cell. 2018;175:1811-1826.
facilities: CSIF, NMS, SBFNL, SFGF In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 2018;32:480-488.
facilities: BioADD Deficits in mesolimbic reward pathway underlie social interaction impairments in children with autism. Brain. 2018:awy191.
facilities: Lucas The hippocampal extracellular matrix regulates pain and memory after injury. Molecular Psychiatry. 2018;23:2302-2313.
facilities: CSIF, GVVC Precision identification of diverse bloodstream pathogens in the gut microbiome. Nature Medicine. 2018.
facilities: Genome Sequencing JAK-STAT signaling is activated in the kidney and peripheral blood cells of patients with focal segmental glomerulosclerosis. Kidney International. 2018;94:795-808.
facilities: HIMC p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Rep. 2018;22:569-575.
facilities: FACS Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations. Nature communications. 2018;9:871.
facilities: TKTC In-depth phenotypic characterization of reticulocyte maturation using mass cytometry. Blood Cells, Molecules, and Diseases. 2018;72:22-33.
facilities: HIMC Diffusion MRI tractography for improved transcranial MRI-guided focused ultrasound thalamotomy targeting for essential tremor. NeuroImage: Clinical. 2018;19:572-580.
facilities: Lucas Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota. Cell. 2018;173:1742-1754.e17.
facilities: BioADD Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers. Science Translational Medicine. 2018;10:eaan6735.
facilities: CSIF, Human Histology A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells. Nature Medicine. 2018;24:1216-1224.
facilities: BioADD miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression. Nature communications. 2018;9:5321.
facilities: Genome Sequencing, SFGF Transmission genetics of drug-resistant hepatitis C virus. eLife. 2018;7:e32579.
facilities: CSIF, FACS, SFGF Detection and Differentiation of Multiple Viral RNAs Using Branched DNA FISH Coupled to Confocal Microscopy and Flow Cytometry. Bio-protocol. 2018;8:e3058.
facilities: CSIF, FACS Cyclin-dependent kinase control of motile ciliogenesis. eLife. 2018;7:e36375.
facilities: CSIF
facilities: GVVC
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Nature communications. 2018;9:5078.
facilities: TKTC Role of the Hof1–Cyk3 interaction in cleavage-furrow ingression and primary-septum formation during yeast cytokinesis. Molecular Biology of the Cell. 2018;29:597-609.
facilities: CSIF Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron. 2018;98:90-108.e5.
facilities: GVVC Magnetic particle imaging of islet transplantation in the liver and under the kidney capsule in mouse models. Quantitative Imaging in Medicine and Surgery. 2018;8:114-122.
facilities: SCi3 CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell. 2018;175:1405-1417.e14.
facilities: CSIF Noninvasive Ultrasonic Drug Uncaging Maps Whole-Brain Functional Networks. Neuron. 2018;100:728-738.e7.
facilities: SCi3 Clinical Evaluation of 68Ga-PSMA-II and 68Ga-RM2 PET Images Reconstructed With an Improved Scatter Correction Algorithm. American Journal of Roentgenology. 2018:1-6.
facilities: PET-MRI Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis. Acta Neuropathologica Communications. 2018;6:4.
facilities: PAN Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons. Vol 9.; 2018. (Nat Commun; vol 9).
facilities: GVVC Artifact‐reduced imaging of biopsy needles with 2D multispectral imaging. Magnetic Resonance in Medicine. 2018;80:655-661.
facilities: Lucas Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas. Nature Medicine. 2018;24:271-281.
facilities: CSIF, SFGF Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept. Vol 13.; 2018. (PLoS One; vol 13).
facilities: HIMC Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer. Theranostics. 2018;8:5126-5142.
facilities: NMS, SCi3 Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nature communications. 2018;9:4144.
facilities: CSIF Dynamic Architecture of DNA Repair Complexes and the Synaptonemal Complex at Sites of Meiotic Recombination. Cell. 2018;173:1678-1691.e16.
facilities: CSIF Regulation of T cell proliferation with drug-responsive microRNA switches. Nucleic Acids Research. 2018;46:1541-1552.
facilities: FACS, PAN NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells. PLOS ONE. 2018;13:e0193126.
facilities: GBSC Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. Journal of Vascular Surgery. 2018;67:573-584.e2.
facilities: SCi3 In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nature communications. 2018;9:5211.
facilities: GVVC, SFGF HIV-1 inhibitory properties of eCD4-Igmim2 determined using an Env-mediated membrane fusion assay. PLOS ONE. 2018;13:e0206365.
facilities: CSIF A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. Molecular Cancer Research. 2018;16.
facilities: HTBC Micro-Positron Emission Tomography for Measuring Sub-core Scale Single and Multiphase Transport Parameters in Porous Media. Advances in Water Resources. 2018;115.
facilities: SCi3 Peripheral TNFα elevations in abstinent alcoholics are associated with hepatitis C infection. PLoS One. 2018;13:e0191586.
facilities: HIMC Imaging cellular pharmacokinetics of 18F-FDG and 6-NBDG uptake by inflammatory and stem cells. PLOS ONE. 2018;13:e0192662.
facilities: The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling. Science Translational Medicine. 2018;10.
facilities: NMS Dynamic and tissue-specific proteolytic processing of chemerin in obese mice. PLOS ONE. 2018;13:e0202780.
facilities: PAN A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription. ACS Chemical Biology. 2018;13:443-448.
facilities: FACS Near-Infrared IIb Fluorescence Imaging of Vascular Regeneration with Dynamic Tissue Perfusion Measurement and High Spatial Resolution. Advanced Functional Materials. 2018;28:1803417.
facilities: SCi3 Rare, high-affinity mouse anti-PD-1 antibodies that function in checkpoint blockade, discovered using microfluidics and molecular genomics. mAbs. 2017;9:1270-1281.
facilities: FACS Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery. The Journal of Immunology. 2017;199:2171-2180.
facilities: HIMC High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization. Immunity. 2017;47:1037-1050.e6.
facilities: FACS Thirst-associated preoptic neurons encode an aversive motivational drive. Science. 2017;357:1149-1155.
facilities: GVVC, TKTC Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex. Neuron. 2017;94:891-907.e6.
facilities: GVVC Persistence of marine fish environmental DNA and the influence of sunlight. PLOS ONE. 2017;12:e0185043.
facilities: SFGF Biomonitoring of marine vertebrates in Monterey Bay using eDNA metabarcoding. PLOS ONE. 2017;12:e0176343.
facilities: SFGF Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist. Neuropharmacology. 2017;116:371-386.
facilities: SBFNL The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline. eLife. 2017;6:e26116.
facilities: Animal Histology, SFGF B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy. Journal of Translational Medicine. 2017;15:9.
facilities: HIMC Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. 2017;544:367-371.
facilities: HIMC, NMS Rabies screen reveals GPe control of cocaine-triggered plasticity. Nature. 2017;549:345.
facilities: GVVC Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects. The Journal of Clinical Investigation. 2017;127:1338-1352.
facilities: HTBC Studying Brain Circuit Function with Dynamic Causal Modeling for Optogenetic fMRI. Neuron. 2017;3:522-532.e5.
facilities: SCi3 Assembly of functionally integrated human forebrain spheroids. Nature. 2017;545:54-59.
facilities: CSIF, GVVC Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures. Neuron. 2017;94:759-773.e8.
facilities: FACS, PAN Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts. Brain Behav. 2017;7:e00710.
facilities: SBFNL Rapid and reversible epigenome editing by endogenous chromatin regulators. Nature Communications. 2017;8:560.
facilities: FACS
facilities: SBFNL
Chart Review Versus an Automated Bioinformatic Approach to Assess Real-World Crizotinib Effectiveness in Anaplastic Lymphoma Kinase–Positive Non–Small-Cell Lung Cancer. JCO Clinical Cancer Informatics. 2017:1-6.
facilities: DCC High-throughput precision measurement of subcellular localization in single cells. Cytometry Part A. 2017;91:180-189.
facilities: PAN A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland. Cell Stem Cell. 2017;20:247-260.e5.
facilities: Animal Histology, NMS, PAN Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk. Nat Genet. 2017;49(8):1202-1210.
facilities: TKTC Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking. Nature. 2017;542:232.
facilities: GVVC Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544:488-492.
facilities: PAN, TASC Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017;20:984-998.
facilities: FACS Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators. Elife. 2017;6.
facilities: FACS, NMS Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nat Med. 2017;23:450-460.
facilities: Animal Histology, CSIF, FACS DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12–CXCR4 signaling axis. Genes & Development. 2017;31:1308-1324.
facilities: Genome Sequencing, PAN, TKTC Imaging and T2 relaxometry of short-T2 connective tissues in the knee using ultrashort echo-time double-echo steady-state (UTEDESS). Magnetic Resonance in Medicine. 2017;78:2136-2148.
facilities: Lucas Advanced-Stage Colorectal Cancer in Persons Younger Than 50 Years Not Associated With Longer Duration of Symptoms or Time to Diagnosis. Clin Gastroenterol Hepatol. 2017;15:728-737 e3.
facilities: DCC Dissociated patterns of anti-correlations with dorsal and ventral default-mode networks at rest. Human Brain Mapping. 2017;38:2454-2465.
facilities: Lucas Soluble intercellular adhesion molecule-1 is associated with hepatocellular carcinoma risk: multiplex analysis of serum markers. Scientific Reports. 2017;7:11169.
facilities: HIMC Systems approach to uncover signaling networks in primary immunodeficiency diseases. Journal of Allergy and Clinical Immunology. 2017;140:881-884.e8.
facilities: HIMC Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis. Nat Med. 2017;23(3):291-300.
facilities: PAN ERBB2-Mutated Metastatic Non-Small Cell Lung Cancer: Response and Resistance to Targeted Therapies. J Thorac Oncol. 2017;12:833-842.
facilities: DCC Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature. 2017;545:477-481.
facilities: GVVC Reducing Functional MR Imaging Acquisition Times by Optimizing Workflow. Radiographics. 2017;37:316-322.
facilities: Lucas An innovative biologic system for photon-powered myocardium in the ischemic heart. Sci Adv. 2017;3:e1603078.
facilities: CSIF, FACS, SCi3 Changes in E-cadherin rigidity sensing regulate cell adhesion. Proc Natl Acad Sci U S A. 2017;114:E5835-E5844.
facilities: CSIF Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis. British Journal of Pharmacology. 2017;174:3284-3301.
facilities: BioADD Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression. Nat Commun. 2017;8:14995.
facilities: HIMC An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Meth. 2017;14:959-962.
facilities: SFGF Loss of [mu] opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nat Med. 2017;23:164-173.
facilities: SFGF Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology. 2017;47:1584-1797.
facilities: HIMC Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy. Nature Communications. 2017;8:14436.
facilities: GVVC Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants. Cell Reports. 2017;18:2592-2599.
facilities: HTBC Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity. The Journal of Experimental Medicine. 2017;214:1081-1092.
facilities: GVVC Doublet asymmetry for estimating polarization in hyperpolarized 13C–pyruvate studies. NMR in Biomedicine. 2017;30:e3670-n/a.
facilities: PET-MRI Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging. Proc Natl Acad Sci U S A. 2017;114:1105-1110.
facilities: HIMC Dynamics of the human antibody repertoire after B cell depletion in systemic sclerosis. Science Immunology. 2017;2:eaan8289.
facilities: HIMC SDF-1 Blockade Enhances Anti-VEGF Therapy of Glioblastoma and Can Be Monitored by MRI. Neoplasia. 2017;19:1-7.
facilities: SCi3 Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells. The Journal of Experimental Medicine. 2017;214:1827-1841.
facilities: FACS Resting-state connectivity biomarkers define neurophysiological subtypes of depression. Nat Med. 2017;23:28-38.
facilities: Lucas Genetic interaction mapping in mammalian cells using CRISPR interference. Nature Methods. 2017;14:577.
facilities: SFGF Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage. Cell Reports. 2017;18:777-790.
facilities: FACS Differential Serum Cytokine Profiles in Patients with Chronic Hepatitis B, C, and Hepatocellular Carcinoma. Scientific Reports. 2017;7:11867.
facilities: HIMC Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients. A Simultaneous Positron Emission Tomography/MRI Study. 2017;48:2441-2449.
facilities: PET-MRI Cerebral blood flow, transit time, and apparent diffusion coefficient in moyamoya disease before and after acetazolamide. Neuroradiology. 2017;59:5-12.
facilities: Lucas CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions. Sci Rep. 2017;7:44810.
facilities: CSIF A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins. Neuron. 2017;93:822-839.e6.
facilities: GVVC Pervasive translational regulation of the cell signalling circuitry underlies mammalian development. Nature Communications. 2017;8:14443.
facilities: FACS Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med. 2017;23:174-184.
facilities: HIMC Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice. Blood. 2017;129:2645-2656.
facilities: PAN Engineering Intracellularly Retained Gaussia Luciferase Reporters for Improved Biosensing and Molecular Imaging Applications. ACS Chemical Biology. 2017.
facilities: PAN Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. European Radiology. 2017;27:732-740.
facilities: Lucas Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors. Science Translational Medicine. 2017;9:eaaf2968.
facilities: Animal Histology, SCi3 Identifying specificity groups in the T cell receptor repertoire. Nature. 2017;547:94-98.
facilities: FACS, HIMC Hydrothermal vent fields discovered in the southern Gulf of California clarify role of habitat in augmenting regional diversity. Proceedings of the Royal Society B: Biological Sciences. 2017;284.
facilities: SFGF PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. 2017;545:495-499.
facilities: CSIF, HIMC, SCi3 Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma. Proceedings of the National Academy of Sciences. 2017;114:4300-4305.
facilities: SFGF, TASC Simultaneous PET/MR imaging with a radio frequency-penetrable PET insert. Medical Physics. 2017;44:112-120.
facilities: Lucas An in vitro model of intestinal infection reveals a developmentally regulated transcriptome of Toxoplasma sporozoites and a NF-κB-like signature in infected host cells. PLOS ONE. 2017;12:e0173018.
facilities: SFGF Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy. J. Vis. Exp.. 2017;(124):e55579.
facilities: NMS Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging. Frontiers in Immunology. 2017;8(692).
facilities: HIMC Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan. Nature. 2017;544:185-190.
facilities: SFGF Initial Experience With Simultaneous 18F-FDG PET/MRI in the Evaluation of Cardiac Sarcoidosis and Myocarditis. Clinical Nuclear Medicine. 2017;42:e328-e334.
facilities: PET-MRI DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells. Nat Meth. 2017;14:479-482.
facilities: NMS Identification of key regions and residues controlling Aβ folding and assembly. Scientific Reports. 2017;7:12434.
facilities: BioADD Imaging of Tumor-Associated Macrophages in a Transgenic Mouse Model of Orthotopic Ovarian Cancer. Molecular Imaging and Biology. 2017;19(5):694-702.
facilities: SCi3 Measurements of translation initiation from all 64 codons in E. coli. Nucleic Acids Res. 2017;45:3615-3626.
facilities: FACS Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo. Proceedings of the National Academy of Sciences. 2017;114:E9153-E9162.
facilities: CSIF Biodistribution and radiation dosimetry of 18F-FTC-146 in humans. Journal of Nuclear Medicine. 2017;58(12):2004-2009.
facilities: PET-MRI Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength. Proceedings of the National Academy of Sciences. 2017;114(6):6675-6684.
facilities: FACS, HTBC, SCi3, SFGF Adjustment for Variable Adherence Under Hierarchical Structure: Instrumental Variable Modeling Through Compound Residual Inclusion. Medical Care. 2017;55(12):e120-e130.
facilities: HIMC Chelator-Free and Biocompatible Melanin Nanoplatform with Facile-Loading Gadolinium and Copper-64 for Bioimaging. Bioconjugate Chemistry. 2017;28:1925-1930.
facilities: SCi3 Combinatorial Extracellular Matrix Microenvironments for Probing Endothelial Differentiation of Human Pluripotent Stem Cells. Sci Rep. 2017;7:6551.
facilities: SFGF Rapid increase in genetic diversity in an endemic Patagonian tuco-tuco following a recent volcanic eruption. Journal of Mammalogy. 2017;98:779-792.
facilities: PAN Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair. JCI insight. 2017;2(19):e96260.
facilities: BioADD Gating of social reward by oxytocin in the ventral tegmental area. Science. 2017;357(6358):1406-1411.
facilities: GVVC Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects. Science Translational Medicine. 2017;9(407):eaad4000.
facilities: BioADD Identification of a novel mutation in the APTX gene associated with ataxia-oculomotor apraxia. Molecular Case Studies. 2017;3(6):a002014.
facilities: Genome Sequencing iSeq: A New Double-Barcode Method for Detecting Dynamic Genetic Interactions in Yeast. G3: Genes|Genomes|Genetics. 2017;7:143-153.
facilities: Genome Sequencing, PAN [18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease. Theranostics. 2017;7:1422-1436.
facilities: SCi3 Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature. 2017;545:234-237.
facilities: Animal Histology Wild immunology assessed by multidimensional mass cytometry. Cytometry Part A. 2017;91:85-95.
facilities: HIMC Pilot Study of 64Cu(I) for PET Imaging of Melanoma. Scientific Reports. 2017;7:2574.
facilities: SCi3 Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism. Mol Psychiatry. 2017;22:375-383.
facilities: GVVC Visualization of Aspergillus fumigatus biofilms with Scanning Electron Microscopy and Variable Pressure-Scanning Electron Microscopy: A comparison of processing techniques. Journal of Microbiological Methods. 2017;132:46-55.
facilities: CSIF Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes. PLoS One. 2017;12:e0171418.
facilities: CSIF Continuous immunotypes describe human immune variation and predict diverse responses. Proc Natl Acad Sci U S A. 2017;114:E6097-E6106.
facilities: HIMC Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis. Bioeng Transl Med. 2017;2:81-91.
facilities: CSIF Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation. Clinical & Experimental Immunology. 2017;189:268-278.
facilities: HIMC Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy. Cardiovascular Diabetology. 2017;16:142.
facilities: SCi3 Toxoplasma gondii MAF1b Binds the Host Cell MIB Complex To Mediate Mitochondrial Association. mSphere. 2017;2:e00183-17.
facilities: NMS Disrupted brain network functional dynamics and hyper-correlation of structural and functional connectome topology in patients with breast cancer prior to treatment. Brain Behav. 2017;7:e00643.
facilities: Lucas Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment. Journal of Biomedical Science. 2017;24:33.
facilities: TKTC Blocking promiscuous activation at cryptic promoters directs cell type–specific gene expression. Science. 2017;356:717-721.
facilities: CSIF, Fly Facility, PAN, SFGF Microfibrous Scaffolds Enhance Endothelial Differentiation and Organization of Induced Pluripotent Stem Cells. Cellular and Molecular Bioengineering. 2017;10(5):417-432.
facilities: CSIF Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor. Oncotarget. 2017;8:52345-52356.
facilities: HTBC, TKTC Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking. Cell. 2017;170:1013-1027.e14.
facilities: GVVC, PAN Time-gated detection of protein-protein interactions with transcriptional readout. eLife. 2017;6:e30233.
facilities: FACS Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression. The Journal of Experimental Medicine. 2017;214:1901-1912.
facilities: SFGF Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system. Nature Communications. 2017;8:2212.
facilities: FACS Biosynthesis of cabbage phytoalexins from indole glucosinolate. Proc Natl Acad Sci U S A. 2017;114:1910-1915.
facilities: SFGF PET/MRI of metabolic activity in osteoarthritis: A feasibility study. Journal of Magnetic Resonance Imaging. 2017;45:1736-1745.
facilities: PET-MRI Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. Cell. 2017;169:407-421.e16.
facilities: PAN Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Reports. 2017;20:1978-1990.
facilities: HIMC Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling. eLife. 2017;6:e20172.
facilities: CSIF Genes co-amplified with ERBB2 or MET as novel potential cancer-promoting genes in gastric cancer. Oncotarget. 2017;8:92209-92226.
facilities: SFGF Dynamic CT imaging of volumetric changes in pulmonary nodules correlates with physical measurements of stiffness. Radiotherapy and Oncology. 2017;122:313-318.
facilities: BioADD, SCi3 Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Nature Communications. 2017;8:14686.
facilities: SFGF The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines. PLOS ONE. 2017;12:e0183594.
facilities: FACS Tethering Growth Factors to Collagen Surfaces Using Copper-Free Click Chemistry: Surface Characterization and in Vitro Biological Response. ACS Applied Materials & Interfaces. 2017;9:23389-23399.
facilities: HTBC, PAN Comparison of CyTOF assays across sites: Results of a six-center pilot study. Journal of Immunological Methods. 2017.
facilities: HIMC 3D Cartesian MRI with compressed sensing and variable view sharing using complementary poisson-disc sampling. Magnetic Resonance in Medicine. 2017;77:1774-1785 .
facilities: Lucas Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease. Proceedings of the National Academy of Sciences. 2017;114:7089-7094.
facilities: HIMC Atomic structure of sensitive battery materials and interfaces revealed by cryo–electron microscopy. Science. 2017;358( 6362):506-510.
facilities: CSIF Feedback regulation of steady-state epithelial turnover and organ size. Nature. 2017;548:588-591.
facilities: CSIF Speckle-modulating optical coherence tomography in living mice and humans. Nature Communications. 2017;8:15845.
facilities: NMS Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481-487.
facilities: FACS Single-cell epigenomic variability reveals functional cancer heterogeneity. Genome Biology. 2017;18:15.
facilities: SFGF Workflow optimization of whole genome amplification and targeted panel sequencing for CTC mutation detection. npj Genomic Medicine. 2017;2:34.
facilities: Genome Sequencing, SFGF Genome-Wide Temporal Profiling of Transcriptome and Open-Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs. Circulation Research. 2017;121:376-391.
facilities: Genome Sequencing, NMS Improved positron emission tomography imaging of glioblastoma cancer using novel 68Ga-labeled peptides targeting the urokinase-type plasminogen activator receptor (uPAR). Amino Acids. 2017;49:1089-1100.
facilities: SCi3 Intratendinous Injection of Hydrogel for Reseeding Decellularized Human Flexor Tendons. Plastic and Reconstructive Surgery. 2017;139:1305e-1314e.
facilities: CSIF, FACS, SCi3 Ancestral Circuits for the Coordinated Modulation of Brain State. Cell. 2017;171:1411-1423.e17.
facilities: GVVC DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes. Cell Reports. 2017;20:819-831.
facilities: FACS, HIMC, SFGF Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury. Proceedings of the National Academy of Sciences. 2017;114:E8072-E8080.
facilities: CSIF, FACS MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis. Cell Reports. 2017;20:1533-1542.
facilities: CSIF The hypothalamic NPVF circuit modulates ventral raphe activity during nociception. Scientific Reports. 2017;7:41528.
facilities: CSIF Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling. Nat Mater. 2017;16.
facilities: FACS, PAN Characterizing CD137 upregulation on NK cells in patients receiving monoclonal antibody therapy. Annals of Oncology. 2017;28:415-420.
facilities: HIMC Formation of Polymeric Nanocubes by Self-Assembly and Crystallization of Dithiolane-Containing Triblock Copolymers. Angewandte Chemie International Edition. 2017;56:16357-16362.
facilities: CSIF Practical ImmunoPET radiotracer design considerations for human immune checkpoint imaging. Journal of Nuclear Medicine. 2017;58:538-546.
facilities: SCi3 Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals. Proceedings of the National Academy of Sciences. 2017;114:E448-E456.
facilities: CSIF, FACS Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes & Development. 2017;31:1095-1108.
facilities: Animal Histology TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin. Nat Struct Mol Biol. 2017;24:344-352.
facilities: SFGF Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology. 2017.
facilities: FACS Conspicuity of Malignant Lesions on PET/CT and Simultaneous Time-Of-Flight PET/MRI. PLOS ONE. 2017;12:e0167262.
facilities: PET-MRI Prospective Evaluation of 68Ga-RM2 PET/MRI in Patients with Biochemical Recurrence of Prostate Cancer and Negative Conventional Imaging. Journal of Nuclear Medicine. 2017.
facilities: PET-MRI Semiquantitative Assessment of (18)F-FDG Uptake in the Normal Skeleton: Comparison Between PET/CT and Time-of-Flight Simultaneous PET/MRI. AJR Am J Roentgenol. 2017:1-7.
facilities: PET-MRI A Novel Theranostic Strategy for MMP-14–Expressing Glioblastomas Impacts Survival. Molecular Cancer Therapeutics. 2017;16:1909-1921.
facilities: SCi3 Cytokine signature associated with disease severity in chronic fatigue syndrome patients. Proceedings of the National Academy of Sciences. 2017;114:E7150-E7158.
facilities: HIMC Reply to Roerink et al: Methods for recruitment, serum separation, and storage were the same for patients and controls. Proceedings of the National Academy of Sciences. 2017;114:E9436.
facilities: HIMC Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers. Elife. 2017;6.
facilities: HIMC Small-Volume Injections: Evaluation of Volume Administration Deviation From Intended Injection Volumes. Anesthesia & Analgesia. 2017;125:1192-1199.
facilities: BioADD Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis. Journal of Allergy and Clinical Immunology. 2017;139:889-899.e11.
facilities: HIMC Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Nature Genetics. 2017;49:1602.
facilities: SFGF C1orf64 is a novel androgen receptor target gene and coregulator that interacts with 14-3-3 protein in breast cancer. Oncotarget. 2017;8:57907-57933.
facilities: SFGF Development of Novel ImmunoPET Tracers to Image Human PD-1 Checkpoint Expression on Tumor-Infiltrating Lymphocytes in a Humanized Mouse Model. Molecular Imaging and Biology. 2017;19:903-914.
facilities: SCi3 Pseudomonas phage inhibition of Candida albicans. Microbiology. 2017.
facilities: CSIF Oral administration of the nitroxide radical TEMPOL exhibits immunomodulatory and therapeutic properties in multiple sclerosis models. Brain, Behavior, and Immunity. 2017;62:332-343.
facilities: PAN A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity. Elife. 2017;6.
facilities: GVVC Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLoS One. 2017;12:e0179606.
facilities: HIMC Spatial distribution of environmental DNA in a nearshore marine habitat. PeerJ. 2017;5:e3044.
facilities: SFGF A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15. Frontiers in Immunology. 2017;8.
facilities: PAN Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 2017;93:897-913.e7.
facilities: PAN Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. PLoS One. 2017;12:e0171898.
facilities: SFGF A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix. Molecular Biology of the Cell. 2017;28:1959-1974.
facilities: CSIF, NMS Sutureless microvascular anastomosis with the aid of heparin loaded poloxamer 407. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2017;70:267-273.
facilities: BioADD Cloud-based interactive analytics for terabytes of genomic variants data. Bioinformatics. 2017;33:3709-3715.
facilities: GBSC, Genome Sequencing Whole-body PET/MRI of Pediatric Patients: The Details That Matter. JoVE. 2017;(130):e57128.
facilities: PET-MRI In vivo assessment of intracellular redox state in rat liver using hyperpolarized [1-13C]Alanine. Magnetic Resonance in Medicine. 2017;77:1741-1748.
facilities: PET-MRI Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia. Biomedicines. 2017;5.
facilities: HIMC Evaluating flow cytometer performance with weighted quadratic least squares analysis of LED and multi-level bead data. Cytometry Part A. 2017;91:232-249.
facilities: FACS A Localized Complex of Two Protein Oligomers Controls the Orientation of Cell Polarity. mBio. 2017;8:e02238-16.
facilities: PAN